The big-serving South African, who stands 6-foot-8 and towered over his opponents, achieved a career-high ranking of fifth in the world in 2018 before sliding out of the top 100 after a succession of knee, shoulder and ankle injuries.
“I've experienced so many different challenges and emotions, this sport can be exhilarating and at the same time lonely. I've had ups and downs, but I wouldn't change it for anything,” he said in a statement on Twitter.
“My journey helped me become the man who I am today. Today I finally arrived at the difficult decision to retire from professional tennis.
“As a kid, my dad used to tell me that success isn't defined by results, but by the effort and sacrifice you make along the way in becoming the best you can be. I gave it my best.”
Having come through the US college system, Anderson turned professional in 2007.
He came close to winning a Grand Slam twice, losing the US Open final in 2017 and the Wimbledon final in 2018 to Rafa Nadal and Novak Djokovic respectively. — Reuters